Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3, and tumor necrosis factor alpha -308 promoter: Non-association with endometriosis
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چکیده
منابع مشابه
Interleukin-4 (IL-4) Inhibits Secretion of IL-lfl, Tumor Necrosis Factor a, and IL-6 by Human Monocytes
Monocytes activated by lipopolysaccharide (LPS) and interferon y (IFNy) rapidly secrete a number of monokines with different functional properties. Interleukin-4 (IL-41, a T-cell derived cytokine, has been shown to reduce the production of monokines with cytostatic activity for tumor cells, chemotactic activity for monocytes, and factors that stimulate thymocyte proliferation. This latter activ...
متن کاملassociation between the polymorphisms of il-4 gene promoter (-590c>t), il-13 coding region (r130q) and il-16 gene promoter (-295t>c) and allergic asthma
allergic asthma is a multifactorial disease, influenced by genetic and environmental factors. recent family-based studies have revealed evidence for linkage of human chromosomes 5q31-33, 12q15-24, 11q13 and 15q23.6 as regions likely to contain genes related to asthma. among the candidate genes in these regions are the genes encoding for human interleukin-4, interleukin-13 and interleukin-16. to...
متن کاملInduction of interleukin-4 (IL-4) by legionella pneumophila infection in BALB/c mice and regulation of tumor necrosis factor alpha, IL-6, and IL-1beta.
Infection of BALB/c mice with a sublethal concentration of Legionella pneumophila causes an acute disease that is resolved by innate immune responses. The infection also initiates the development of adaptive Th1 responses that protect the mice from challenge infections. To study the early responses, cytokines induced during the first 24 h after infection were examined. In the serum, interleukin...
متن کاملAssociation of IL-4 promoter polymorphisms with asthma: a meta-analysis.
This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly associated ...
متن کاملThe association between interleukin-4 -590C/T genetic polymorphism, IL-4 serum level, and advanced endometriosis
AIM OF THE STUDY Aim of the study was to investigate interleukin (IL)-4 serum levels in patients with advanced endometriosis and whether IL-4 promoter region (-590C/T) genetic polymorphism is involved in genetic susceptibility to endometriosis. MATERIAL AND METHODS IL-4 serum levels and IL-4 -590C/T genetic polymorphism were determined for 80 patients with advanced endometriosis and 85 health...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 2002
ISSN: 0887-8013,1098-2825
DOI: 10.1002/jcla.10021